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Pycock C, Anlezark G, Pieri L, Pieri M, Haefely W. 
“LSD and Dopamine Receptors”. 
Nature. 1975;257(5521):69-70.
The effect of LSD in rats with unilateral chemical lesions of the forebrain and other model, is reported and compared with earlier ,work (Nature 252 586 1974). In mice, pretreated with either 6 - hydroxydopamine,or 5,6 dihydroxytryptamine-LSD produced apomorphine like circling behavior in-40-500f mice and then onlyat doses of 1-1.5 mg/kg the turning-mouse model- LSD (0.025-0.2-'mg/kg) alone did not induce turning behavior nor did it modify apomorphine or amphetamineinduced circling. Rotation was induced by LSD, (1.5- mg/k'g) with a duration of 35-45 min; thus rotation was prevented by pretreatment with haloperidol (O.5 mg/kg) but not by a-methyl-p-tyrosine (250--mg/kg). In blocking audiogenic seizures in mice, apomorphine was 10 times more active than LSD. The results do support the earlier view that LSD is a potent dopamine agonist. The authors of the previous paper conment that different species and lesion were used which resulted in less denervation super sensitivity as indicated by apomorphine induced turning Dopamine-agonist activiy; is also suggested by the effect on, LSD-(10 6 M) in activating adenylate cyclase and in reducing striatal dopamine turnover.
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