Erowid References Database
Bouver JJ, Dedet L, Verdeaux J, Rougeul A.
“Selective Modification of Spontaneous ECoG Rhythms of the Cat Somesthetic Cortex by Psychoactive Drugs: Behavioral Correlates”.
The effects of 3 psychoactive drugs on the electrocorticograph (ECoG) pattern in conscious cats were investigated. In 30 adult cats under anesthesia, cortical epidural electrodes were implanted in the lateral part of somesthetic area I (SI), the frontal area and the visual area. Cats were given i.p. injections of of d-amphetamine (2 mg/kg), LSD-25 (0.1 mg/kg). Ditran I mg/kg (Lakeside) or essence of eucalyptus placebo. The animal's behaviour was observed by closed TV circuit and ECoG quantified over the first hour and compared to recordings obtained from the same animal under control conditions. The type of rhythm recorded from the SI area in a normal cat and a description of the chronology of wakefulness and sleep were briefly described. Each drug elicited a characteristic alteration of rhythmic patterns in SI. After d-amphetamine the animal displayed periods of immobility interrupted by stereotyped movements. Over periods of immobility the ECoG consisted of fast 36 c/s rhythms similar to those of the normal cat in the exploratory phase. Except for some early short bursts of 14 c/s rhythms, neither slower rhythms nor sleep spindles could be noticed. Fast activities were maintained throughout the hour cf. a maximum of is min under normal test conditons. LSD-25 induced a wakeful but fairly abnormal behaviour. Autonomic signs i.e. mydriasis, piloerection were observed. Somesthetic rhythms were observed on the ECoG but as in the normal cat they developed only during immobility. The qualitative organization of these rhythms was abnormal. The 14 c/s rhythm disappeared while those of 36 c/s were abundant and alternated by 6 c/s rhythm for a prolonged period. After Ditran the cat restlessly explored the cage for several hr. The ECoG displayed a drowsiness pattern for 20 min then traced out spindles and irregular waves resembling the normal sleep pattern with no change for several hr. This pattern was not interrupted by locomotor activity. The psychoactive drugs tested strongly modify the temporal development of the somesthetic rhthymic activities of the cat.
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