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Carino MA, Horita A. 
“Rapid Development Of Tolerance Upon Central Injection Of LSD”. 
Life Sciences. 1977;20:49-56.
LSD given into the lateral ventricle produces a dose-dependent rise in temperature accompanied by behavioral excitation. Tolerance to the pyretogenic effect rapidly develops upon intraventricular (ICY) injection of LSD following an intravenous injection of the same drug. Both Cinanserin and Cyproheptadine attenuate the pyretogenic response induced by LSD. Phenoxybenzamine attenuates the pyretogenic response induced by LSD to a greater degree than Dibozane.
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