Erowid References Database
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Drummond AH, Bucher F, Levitan IB.
“3H-LSD labels. a novel dopamine receptor in molluscan ganglia”.
Experientia. 1978;34(7):923.
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Abstract
3H-LSD binds to both dopamine and serotonin (5HT) receptors in a particulate fraction derived from CNS of Helix pomatia. In the presence of 100 mcM 5HT, binding of 3H-LSD is only to ganglionic dopamine receptors ( > 900ure). This dopamine sensitive LSD-binding is inhibited stereospecifically by d-LSD and d-butaclamol, but not by cis-flupenthixol. Also, while ergot alkaloids are potent inhibitors of binding (Kd /= 0.1 mcM). Dopamine and analogs such as Epinine and (3,4-dihydroxyphenylamine)-2-imidazoline are inhibitory in the micromolar range, as are tryptamine derivatives such as bufotenine, N-methyltryptamine and 6,7 dihydroxytryptamine. This spectrum of pharmacological action is similar to that reported for inhibitory dopaminergic synapses on Helix neurones, but is different from that found at vertebrate dopaminergic receptors.
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