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Harris RA, Snell D, Loh HH, Leake CD.
“Effects Of Hallucinogens On Operant Behavior”.
Fed.Proc.. 1976;35(3):644.
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Abstract
Rats responding on fixed ratio (FR) 30 or fixed interval (Fl) 2 min schedules of food reinforcement were injected with various hallucinogens. All of the hallucinogens tested decreased the rate of FR 30 responding, and their relative potency to produce these rate decreases was highly correlated with their reported human potencies. The dosages (mcmole/kn) of each drum required to reduce FR respondinq by 50% were: LSD, .027; paramethoxyamphetamine (PHA)5.5; 2,4,5-trimethoxyamphetamine (TMA),11; 2,4-dimethoxyamphetamine (DMA), 16; 2,4,6-TMA, 20; 2,5-DMA, 41; 2,3,5-TMA, 63; 2,3,4-TMA,50; 3,4 DMA, 58; 2,3,6-TMA, 75; DMT, 78; mescaline, 90. All of these drugs also decreased the overall rate of Fl responding. However, two of the drugs, LSD and PMA, increased the low rates or F1 responding occurring at the beginning of the interval while decreasing the higher response rates occurring at the end of each interval. The other ten drugs decreased response rates throughout the interval. Thus, in contrast to amphetamine, most of the methoxylated amphetamines, as well as mescaline and DMT, did not display rate-dependent effects. The good correlation between the relative potency of these 12 drugs in disrupting rat operant behavior and their potency in producing subjective effects in humans suggests similarities in the mechanisms underlying these two effects.
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| Notes # : Abstract No 2421 |
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