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Hasimoto H, Hayashi M, Nakahara Y, Niwaguchi T, Ishii H. 
“Hyperthermic Effects of D-Lysergic Acid Diethylamide (LSD) and its Derivatives in Rabbits and Rats”. 
Arch. int. Pharmacodyn. 1977;228:314-321.
Several D-lysergic acid diethylamide (LSD) derivatives including metabolites of LSD in animals liver and Streptomyces such as D-lysergic acid ethyl, 2-hydroxyethylamide (LEO), D-lysergic acid ethylamide (MAE), D-norlysergic acid diethylamide (norLSD) and synthetic Nti-allyl-O-norlysergic acid diethylamide (allyl-nor LSD) were studied with regard to their hyperthermic effect in rabbits and rats. In rabbits, the order of the hyperthermic activities was allyl-norLSD > LSD > LEO, LAE, norLSD, and this order was parallel to that of 5-hydroxytryptamine-like activities of these compounds which was previously studied. However, the order was MAE > LSD > norLSD in rats. The hyperthermic effect of LSD in rabbits as attenuated bar methysergide, but not by atropine when these drugs were intraventricularly administered. These results suggest the possibility that the metabolites of LSD contribute to the hyperthermic effect of LSD in rats but not in rabbits, and support the idea that 5-HT receptors are involved in the hyperthermia induced by LSD in rabbits.
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