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Holbrook L, Brown IR. 
“Disaggregation Of Brain Polysomes After D-lysergic Acid Diethylamide Administration In Vivo: Mechanism And Effect Of Age And Environment”. 
Journal of Neurochemistry. 1977;29:461-467.
The cell-free protein synthesis activity and tRNA content of the increased pool of brain monosomes produced after D-lysergic acid diethylamide (LSD) administration were analyzed. Decreased reinitiation of protein synthesis rather than RNase activation or premature termination was shown to be the mechanism which results in brain polysome disaggregation after administration of the drug in vivo. At a constant dosage of 50mcg/kg the degree of polysome shift increases with age from 3-week-old rabbits to adults. There is also an extensive disaggregation of fetal brain polysomes when LSD is administered maternally. The LSD-induced polysome shift was shown to be altered by holding cage environment, pre-LSD sedation and post-LSD handling with brief restraint. It was apparent that elements of environment and physiological arousal were involved in the macromolecular effect of the drug on the protein synthesis apparatus of the brain.
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