Erowid References Database
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Horowski R.
“Differences in the Dopaminergic Effects of the Ergot Derivatives Bromocriptine, Lisuride and d-LSD as compared with Apomorphine”.
Eur J Pharmacol. 1978;51(2):157-66.
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Abstract
Differences in the dopaminergic effects of the ergot derivatives bromocriptine, lisuride and d-LSD were demonstrated as compared with apomorphine. Methods Female NMRI mice (18-25 g, Schering) receiving Altromin - as a standard diet were pretreated with reserpine (Serpasil, to mg/kg, i.p. ClBA-Geigy) alone or in combination with n-methyl p-tyrosine (H44/68 Haessle, 250 mg/kg, i.p.) or with sulpiride (Delagrange). Stereotyped behavior was observed and the effects of the following drugs were tested: apomorphine (Sandoz 1.56 mg/kg), lisuride (Spofa, 0.07-0.26 mg/kg, s.c.), 1.56 mg/kg, i.p. and dLSD (Spofa, 1.56 mg/kg, i.p.) 30 min and bromocriptine (Sandoz, 0.19-0.62 mg/kg, i.p., 25 mg/kg, s.c.) 2 hr after injection. Results Hypothermia induced by apomorphine or lisuride was inhibited by pretreatment with sulpiride without affecting stereotyped behavior. In reserpine-pretreated mice, apomorphine lisuride, LSD and bromocriptine restored motor activity to some extent, antagonized reserpine hypothermia and (with the exception of bromocriptine) produced stereotyped behavior. Only the effects caused by bromocriptine could be abolished completely by low doses of sulpiride, whilst high doses of this drug had little effect on the activity of other dopaminergic agonists Inhibition of tyrosine hydroxylase by a-methyl-p-tyrosine completely prevented the effects of bromocriptine but only slightly affected lisuride and LSD actions. It had no effect on the activity of apomorphine.
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