Erowid References Database
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Kapturkiewicz Z, Sowinska H.
“The Effect of Piribedil on Body Temperature in Mice and Rats”.
Pol.J.Pharmacol.Pharm.. 1977;29(6):609-18.
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Abstract
The effects of piribedil on body temperature in mice and rats were investigated. Methods Piribedil (PB; Trivastal, Servier) was given i.p. to Wistar rats (140-190 g) at 25,50 or 100 mg/kg and albino Swiss mice (18-25 g) at 50 or 100 mg/kg ipo Animals were untreated or treated with: spiperone (SP; Janssen) to rats (0.4 mg/kg) and mice (1.2 mg/kg);pimozide (PIM; Janssen) to mice (1 mg/kg); cyproheptadine (CYP; Merck-USA) to rats (0.5 mg/kg), p-chlorophenylalanine (PCPA; Sigma) to rats (3 doses of 300,100 and 100 mg/kg), lysergide (LSD, Sandoz) to rats (1 mg/kg); imipramine (IMP; Polfa) to mice (10 mg/kg), clomipramine (CIMP; Anafranil, CIBA-Geigy) to mice (20 mR/kg). desipramine (DIP; Pertofran, CIBA-Geigy) to mice (10 mgkg); or atropine (ATR; Polfa) to rats (5 mg/kg). Body temperatures were recorded every 30 min. Piribedil produced hypothermia in both rats and mice prevented by SP and PIM. Pre-treatment with compounds affecting serotonin neurons (CYP, PCPA or LSD) or atropine did not affect the onset of hypothermia. Among the tricyclic antidepressants, DIP and IMP prevented hypothermia, whilst CIMP (20 mg/kg) had a transient effect. DIP was the most potent compound, completely preventing hypothermia induced by 50 mg/kg PB in rats and causing a slight increase in mouse body temperature over controls. It was suggested that the hypothermia produced by PB involving DA and 5-HT systems may, as in the case of apomorphine, be the result of secondary stimulation of 5-HT receptors developing as a result of a direct action of PB on DA receptors.
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