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Martin P, Consroe P. 
“Cannabinoid Induced Behavioral Convulsions in Rabbits”. 
Science. 1976;194(No.4268):965-67.
The behavioral effects of i.v. administration of psychoactive cannabino”ds were investigated in rabbits. Various doses of different cannabinoids were given i.v. to 2.53.3 kg New Zealand white rabbits and subsequent behavioral changes were noted, Results id THG (tetrahydrocannabinol), THC, SP-111A (Sharps Associates) and 11-hydroxy-delta-9-THC in doses of 0.25-1.0 mg/kg all produced convulsions which were qualitatively similar but differed in latency of onset. SP-111A had the longest latency at 461.8 + 46.08 see and 11-hydroxy-9 THC the shortest at 20.9 + 3.81 sec. Gamma-morpholinobutyric acid and Tween-81-saline which were used as vehicles did not produce convulsions. Convulsions were produced by 10-15 mg/kg cannabinol but not by 10-20 mg/kg of cannabidiol. Cannabichromene 8.0 mg/kg was also without effect. However when the same dose of cannabicyclol was given to 2 rabbits, 1 was unaffected but the other went into convulsion about 7 min after drug administration and then died. LSD 100 mcg/kg, mescaline 40.0 mg/kg, psilocybin 3.0 mg/kg, phencyclidine 2.0 mg/kg and methamphetamine 0.5 mg/kg did not produce convulsions. Tolerance was produced by daily doses of 0.5 mg/kg 9 THC, however tolerance was lost 1 wk after the last dose of the drug had been given. The New Zealand white rabbit may be used as an animal model for evaluating the effects of cannabinoids and potential antagonists in man.
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