Erowid References Database
Martin WR, Sloan JW, Vaupel DB.
“Tryptamine in the Brain and Spinal Cord: Its Role in the LSD Response”.
The role of tryptamine in the LSD response is reviewed. Tryptamine administration in the chronic spinal dog produces a syndrome characterized by facilitation of the flexor reflex' evocation of the stepping reflex' purse' temperature and respiratory rate increase' similar to that produced by LSD and mescaline, psilocin and DOM. These effects have been produced by i.v. administration in man. Tolerance to the effects of LSD in the chronic spinal dog and cross tolerance of tryptamine could be demonstrated. Release of tryptamine from cerebral cortex, caudate, hippocampus etc. is decreased by pentobarbital anesthesia and increased by monoamine oxidase inhibition in the dog. In the acute decerebrate cat tryptamine decreased mono- and polysynaptic reflexes when the spinal cord was isolated from afferent input by a section of the dorsal roots. This facilitatory action was blocked by cyproheptadine whereas phenoxybenzamine blocked the effects of methoxamine. Tryptamine facilitated the C-fiber reflex as did LSD and L-tryptophan and this effect was blocked by n-methyldopa and cyproheptadine but not by fenclonine. 5-Hydroxytryptophan did not facilitate the C-fiber reflex. L-tryptophan facilitated the C-fiber reflex in the acute spinal cat but not in the chronic spinal dog, while LSD had a greater facilitatory effect in the chronic spinal rat than in the acute spinal rat. LSD-like hallucinogens cause reflex facilitation by acting as tryptaminergic agonists, The function of tryptaminergic neurons could have psychiatric importance e.g. low activity could contribute to hypophoria while over-activity could lead to thought disorders and preceptual distortions.
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