Erowid References Database
|
Persson SA.
“Effects Of LSD And 2-Bromo LSD On Striatal Dopac Levels”.
Life Sciences. 1977;20:1199-1205.
|
|
Abstract
Administration of d-lysergic acid diethylamide (LSD) and its analogue 2-bromo lysergic acid diethylamide (BOL) resulted in a shortlasting increase of 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the rat striatum. BOL was more potent than LSD in the dose range 0.5-4.0 mg/kg. Since there was a concomitant increase in the striatal in viva tyrosine hydroxylation as measured by DOPA accumulation after decarboxylase inhibition, our findings suggest that LSD and BOL increase the impulse flow in the nigro-neostriatal pathway probably by central dopamine (DA) receptor antagonism. However, 4 has after) LSD the DOPAC level was decreased, while the DOPA accumulation was not. Thus the effect of LSD on the dopaminergic system appears not to be limited to a pure receptoridantagonism. The possibility also exists that the effect of LSD on the nigro-neostriatal DA pathway is secondary to its effect on the central 5-hydroxytryptaminergic system.
|
| # |
| Submit Comment |
|
[
Cite HTML ]
