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Schlemmer RF, Tyler CB, Narasimhachari N, Davis JM. 
“The Comparitive Effects Of LSD, Mescaline, And DMT On Primate Social And Solitary Behavior”. 
Federation Proceedings. 1978;37(3):659.
Abstract
To study the effect of hallucinogens on primate behavior, 3 chemically diverse hallucinogens-d-LSD, mescaline (MESC), and dimethyltryptamine (DMT)- were administeed chronically to 2 pairs of adult Stumptail macaaue females housed in separate cages. Following a 5-day baseline observation period, MESC (17 mg/kg), DMT (2 mg/kg), or LSD (0.1 mg/kg) was administered daily i.m. to each of the 4 monkeys for 5 days. Only 1 monkey/pair received drug each wk and 1 wk elapsed between the different treatments. MESC, DMT and LSD were given 60, 5, and 15 minutes prior to observation respectively. Observation by a “blind” observer occured for 1 hour daily for each group. MESC, DMT & LSD all induced dog-like “wet shakes” and involuntary limb jerks. There was evidence of tolerance to LSD and MESC, but not DMT, for each of these behaviors. Only DMT induced hypervigilance and this showed tolerance. All three drugs significantly decreased social and self grooming. Only MESC and LSD significantly increased resting scores. Wet shakes and limb jerks appear to be the most unique behaviors induced by hallucinogens in this species since 35 non-hallucinogenic psychoactive drugs tested did not induce these 2 behaviors. This study also demonstrates both similarities and differences in the behavioral changes induced by hemically diverse hallucinogens in monkeys. This paradigm may prove useful in the study of the psychopharmacology of hallucinogens.
Notes # : Abstr. No. 2344
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