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Trulson ME, Jacobs BL. 
“Effects Of LSD On Behavior And Raphe Unit Activity In Freely-moving Cats”. 
Fed. Proc.. 1978;37(3):346.
Single unit activity was recorded in the dorsal raphe nucleus of freely moving cats via chronically implanted nichrome wires, while simultaneously quantifying LSD-induced behavioral changes (e.g. limb flicking and abortive grooming). LSD at a dose of 10 mcg/kg ip decreased raphe unit activity 10-15 0.000000rom a quiet waking baseline and produced an average of 12 limb flicks per hour, while a dose of 50 mcgkg decreased raphe firing approximately 70% and elicited 45 limb flicks per hour. Following the 50 mcg/kg dose of LSD, raphe unit activity returned to baseline levels within 3-4 hours, while the behavioral changes persisted for at least 8 hours. Twenty-four hours after the initial dose of LSD (50 mcg/kg), a second dose of 50 mcg/kg of LSD was virtually without behavioral effect (i.e. tolerance), but produced an 80 0ecrease in raphe unit activity from a quiet waking baseline. In conclusion, these data provide support for a causal relationship between LSDs inactivation of central serotonergic neurotransmission and the behavioral effects of the drug. Furthermore, tolerance to LSD is apparently not mediated by a change at the raphe neuron level.
Notes # : Abstr. No. 717
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