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Wyatt RJ, Cannon EH, Stoff DM, Gillin JC.
“Interactions of Hallucinogens at the Clinical Level”.
Ann.N.Y.Acad.Sci.. 1976;281:456-86.
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Abstract
Interactions of hallucinogens with drugs and themselves are discussed. Studies have been made of interactions of 1) LSD with LSD chlorpromazine (CPZ), reserpine, frenquel, nicotinic acid, sodiu Amytal, peruitin, phenoxybenzamine, ergotam“ne, isocarboxide, tetrabenzine, traylcypromine, serotonin, propranolol, c-methyl p-tyrosine (AMPT), disulfiram, desrrlethylimipramine, p chlorophenylalanine, cyprophetadine and 1 ,methyl- 1,2 ,5,6-tetrahydropyridine 3-'N,N-diethylcarboxamide) (THPC); 2) N,N-dime' yltryptamine and iproniazid, methysergide, CPZ, Haldol, thiothi ene, molindone, methiothepin, octoclothepin, N,N-diethylbutyramide, and aloperidol; 3) mescaline with CPZ, frenquel, phenothiazine, diethazine, c rypr oheptadine, phenoxyb enzamine, 2,4,5-trimethoxyphenylethyamine, THPC, haloperidol and thioridazine, 4) psilocin or psilocybin with CPZ, cryproheptadine reserpine and AMPI; 5) 5-methoxy-DMT with CPZ, reserpine, 5-HTP, disulfiram, l-dopa, tranylcypromine, SK-525A, pargyline, pCPA and dihydroxyphenylserine. Many studies show that tolerance develops to the autonomic and psychological effects of LSD, mescaline, DOM and psilocybin in man. Only 1 human study with DMT has been made and tolerance did not develop. Pretreatment with BOL-148 did not protect against LSD effects in another study. A 2-way partial cross tolerance appears to exist between LSD, mescaline and psilocybin. There may be separate mechanisms for the effects and formation of tolerance, depending on whether the route of administration is central or peripheral. Cross-discrimination responding studies tend to be consistert with cross tolerance studies. Applications to treatment of effects of hallucinogens are discussed.
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