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North RA, Henderson G, Katayama Y, Johnson SM. 
“Electrophysiological Evidence For Presynaptic Inhibition Of Acetycholine Release By 5-hydroxytryptamine In The Enteric Nervous System”. 
Neuroscience. 1980;5:581-6.
Intracellular recordings were made in vitro from myenteric neurons of guinea pig ileum, 5-hydroxytryptamine was applied to the preparation either by superfusion or by iontophoresis on to the somatic membrane of the impaled cells. 5-Hydroxytryptamine (50 nM-2 mcM) depressed the amplitude of the cholinergic fast excitatory postsynaptic potential in every neuron to which it was applied (n = 58). 5-Hydroxytryptamine did not change the amplitude of depolarizations produced by iontophoretic application, off acetylcholine which were of a similar time course to the excitatory postsynaptic potential. Lysergic acid diethylamide (1 mcM) and methysergide (I-30 mcM) mimicked and sometimes blocked the action of 5-hydroxytryptamine. The results indicate that the inhibition of the peristaltic reflex by 5-hydroxytryptamine may be due to a blockade of transmission within the myenteric plexus brought about by a presynaptic action.
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