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Ruch Monachon MA, Jalfre M, Haefely W.
“Drugs and PGO Waves in the Lateral Geniculate Body of the Curarized Cat. II. PGO Wave Activity and Brain 5-Hydroxytryptamine”.
Arch.Intern.Pharmacodyn.. 1976;219(2):269-86.
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Abstract
Ponto-geniculo-occipital (PGO) waves were measured to atudy drugs that interact with central 5-hydroxytryptaminergic mechanisms, in curarized cats. Methods The preparation of cats and induction of PGO1284 waves with i.p. Ro 4-1284, and PGOpcpa waves with i.p. p-chlorophenylalaine (PCPA) were as previoualy described. Drugs were administered either i.v. or intraventricularly. Results Of the precursors of 5-hydroxytryptamine (5-HT), both 1-tryptophan and 5-hydroxytryptophan (5-HTP) depressed PGO1284 but only 5-HTP affected PGOpca waves. No significant effect was seen with 5-HT though the tendency was depresaion of PGO1284. Tryptophan had no significant effect. LSD was a very potent depressant of PGOI284, methysergide was half as potent and the bromo analog of LSD only 1/10th as potent. LSD was just as potent indepressing PGOpcpa waves. Psilocybin was at least as potent as LSD in reducing the density of PGOI284 waves, N,N-dimethyltryptamine and bufotenine had 1/10th this potency and yohimbine was much less potent. The tricyclic antidepressants depressed the density of PGO1284 with the following order of potency: chlorimipramine> imipramine> amitriptyline > protriptyline > chlordesipramine> dibenzepin > prothiadene> desipramine > noxiptyline ketipramine> doxepin. Melitracene, opipramol, butriptyline maprotiline and iprindole had no effect in doses up to 10 mg/kg, i.v. Maprotiline was very potent in depressing PGOpcpa. Cocaine and quipazine both depressed PGO1284. Of central 5-HT antagonists, cinanserin had no effect, mianserin increased the denaity of PGO1284, and cyprohepadire increased with low doses but depressed with a dose of 10 mg/kg. The most potent potentiators of PGO waves to both drugs were methiothepin and octoclothepin, and the former antagonized the effects of 5-HTP and LSD. Methiothepin (10 mg/kg) in untreated cats induced an immediate continuous discharge of PGO waves lasting several hr.
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