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Heinze WJ, Schlemner RF, Javaid JI, Davis JM. 
“The Comparative Effects of d-LSD & d-Amphetamine on Stereotyped Behavior in Rats”. 
Federation Proceedings. 1981;40(3 part 1).
In this study, the acute & chronic effect of two psychomimetics; d-lysergic acid diethylamide (LSD) & d-amphetamine (dAMPH), on stereotypy was compared in rats. In the 1st expt. adult male Sprague-Dawley rats received 9 acute doses of LSD (0.001 - 5 mg/kg) or d-AMPH (0.1 - 10 mg/kg). In the 2nd expt., one of 2 doses of LSD (0.1 & 2.5 mg/kg) or d-AMPH (1 & 5 mg/kg) were given 1 x daily for 5 consecutive days. In the 3rd expt. the dopamine antagonist haloperidol (HALO), 1 mg/kg, or the serotonin antagonist cinanserin (CINAN), 5 mg/kg, or methysergide (METHY), 5 mg/kg, were given 30 mins. prior to LSD 0.1 or 2.5 mg/kg or d-AMPHET 1, 5, or 10 mg/kg. All drugs & saline (controls) were given -i.p After injection, each rat was observed for 2 hrs in its individual home cage by a "blind" observer who rated stereotypy. d-AMPH 5 - 10 mg/kg induced more intense sniffing, licking, & chewing stereotypies than LSD, although LSD induced these behaviors at lower doses (0.05 - 5 mg/kg) LSD induced stereotyped pawing whereas d-AMPH did not. Tolerance failed to develop to either d-AMPH or LSD-induced stereotyped sniffing, 1icking or chewing although partial tolerance did develop to LSD-induced stereotyped pawing. HALO antagonized all d-AMPH-induced stereotypies but METHY did not. CINAN antagonized LSD-induced stereotyped pawing but HALO did not. These results demonstrate both similarities & differences in the stereotyped behavior induced in rats by these 2 psychotomimetics.
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