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Schlemmer RF, Davis JM. 
“LSD-induced Behavioral Changes In Selected Members Of A Primate Social Colony”. 
Behavioral Pharmacology and Physiology. 1981;2:413-414.
The effect of the potent hallucinogen d-lysergic acid diethylamide (d-LSD) on primate social and solitary behavior was studied in five adult members (1 male, 4 females) of a stable Stumptail macaque social colony. Following a 50-day observation of normal, undrugged behavior (baseline), each monkey in the colony received 5 acute doses of d-LSD, 0.3, 1, 3, 10, and 30 mcg (base)/kg over a 10 wk period in a latin square design. Only 1 monkey received drug treatment/day and 14 days separated each LSD injection to the same animal. d-LSD and saline (during basline) were given i.m. 15 min. prior to observation. A 1 hour behavioral observation of the entire colony was conducted 5 days/wk by a "blind" observer using the focal sampling technique. In general, d-LSD induced abnormal behavior and disrupted normal affiliative behavior. d-LSD induced limb jerks, body shakes, ptosis, and dyskinesias as abnormal behavior at doses greater than 1 mcg/kg. d-LSD significantly decreased social grooming at doses as low as 0.3 mcg/kg and increased distancing from other monkeys at higher doses. However, d-LSD-treated monkeys were approached more frequently by control monkeys than during baseline. d-LSD also significantly decreased self-grooming and food forage in treated monkeys. Checking (vigilance) scores were slightly, but significantly increased by higher doses of d-LSD but locomotion was unaffected. This study demonstrates that d-LSD has profound effects on primate social and solitary behavior ina dose range similar to that used by humans.
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