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Trulson ME, Brandstetter JW, Jacobs BL. 
“Similarity of the behavioral effects of quipazine and LSD in cats”. 
Federation Proceedings. 1981;40(3, Pt 1):267.
Administration of quipazine (0.5 to 5.0 mg/kg, i.p.) to cats elicited a number of behaviors, such as limb flicking, abortive grooming, investigatory and hallucinatory-like behaviors, which we have previously proposed as an animal behavior model for studying the actions of LSD and related hallucinogens. Of these behaviors, the limb flick has proven to be the most sensitive and reliable index of hallucinogenic activity. Quipazine produced a dose-dependent increase in limb flicking, from a saline baseline of virtually 0 to a peak of 29.7 flicks/hr, which is similar to the peak behavioral effect of LSD. The behavioral effects of 5 mg/kg of quipazine persisted for 4 to 6 hours, which is somewhat shorter than that observed following LSD administration. When a second 5 mg/kg dose of quipazine was readministered 24 hrs later, the behavioral changes were not significantly different from those observed after the initial dose. This latter finding is in sharp contrast to the nearly complete tolerance that develops to LSD following a single injection. In summary, the behavioral effects of quipazine in cats are very similar to those observed following LSD, except that no tolerance occurred following repeated administration of quipazine. The present data are consistent with preliminary findings by other investigators indicating that quipazine induces hallucinations in humans.
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