Erowid References Database
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Trulson ME.
“Separation of tolerance to the behavioral effects of LSD from changes in seroronin receptor binding in cats”.
European Journal of Pharmacology. 1985;111(3):385-388.
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Abstract
Nearly complete tolerance to a test dose of 50 mcg/kg of LSD occurred within 24 h following an initial dose of 50 mcg/kg of the drug, using limb flicking and abortive grooming as behavioral indices in the cat. No changes in serotonin receptor binding were observed at this time. However, chronic administration of LSD (50 mcg/kg every 12 h for 6 days) produced a significant decrease in serotonin receptor binding in both the forebrain and brainstem plus spinal cord. These data suggest that the behavioral effects of LSD and tolerance to LSD as measured here are mediated predominantly by different sites.
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