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“Dangers of LSD”.
Lancet. 1967;1967(II):929-930.
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Abstract
Since the psychological effects of lysergic acid diethylamide (LSD) were first recorded by Hoffman in 1943, its central actions have been the subject of increasing interest-and abuse. In 1949, Stoll reported that doses of 30 mg. Of LSD given by mouth to normal subjects produced autonomic changes, predominantly sympathomimetic, visual hallucinations with intense and changing colour, increased auditory and tactile perception, distortions of body image, mood changes, and feeling of estrangement and depresonalisation. During these changes, the subject were able to respond to interrogation and they retained critical self-judgment. At first it was thought that these effects of LSD and other hallucinogenic drugs mimicked schizophrenia and that they might give a clue to its aetiology, but this has proved a false trail. A therapeutic use for LSD was sought in its ability to increase awareness and facilitate insight during psychotherapy, and it was also given in the treatment of alcoholism but the results have been at best controversial and usually disappointing. The most important and disturbing aspect of LSD has been its illicit spread from black market sources, and many reports have appeared of psychotic reactions in people taking the drug without medical supervision.
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