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McGlothlin W, Cohen S, McClothlin MS. 
“Long lasting effects of LSD on normals”. 
Arch Gen Psychiat. 1967;17:521-532.
This is a report of a study designed to measure personality, attitude, value, interest, and performance changes resulting from the administration of LSD to normals. Several investigators using LSD with humans in nontherapy experiments have observed that some of their subjects report various lasting effect attributable to the drug experience. In addition, the recent controversy over the nonmedical use of LSD has given rise to numerous claims and counterclaims in this regard. We have previously reported on a pilot study in which tests of anxiety, attitudes, and creativity were given to 15 subjects prior to, and one week following, a single 200 mg LSD session. Some significant changes in the anxiety and attitude tests were observed, but none were found for the creativity measures. The assessment of lasting effects of hallucinogens involves extradrug variables to a greater extent than do most drug studies. We are asking, in effect, whether a dramatic drug-induced experience-one which temporarily dissolves the primacy of habitual perceptions of self image, environment, beliefs, and values-will have a lasting impact on the individual's personality. We would expect any such impact to be influenced by the person's prior personality, motivation, and expectation, and by the presence of suggestion and reinforcement prior, during, and after the drug experience. In the present study, the subjects volunteered for a paid experiment without prior knowledge of its nature. A large battery of psychological tests was administered prior to a series of three, 200 mg LSD sessions, and again at intervals of two weeks and six months following the third session. The hypothesized postdrug personality changes include those most commonly reported in questionnaire evaluations: (1) lower anxiety; (2) attitude and value changes, primarily characterized by greater introspection, less defensiveness, aggression and rigidity, less materialism and competitiveness, and greater tolerance toward others; (3) increased creativity; and (4) enhanced interest and appreciation of music and art.
Notes # : Identical paper to LSD 1668, Erowid Ref ID 4655. This is an error in the original Hofmann Collection, where the same paper was entered twice and assigned two distinct LSD IDs (1553 and 1668). Also note that another version of this paper was published separately and assigned LSD ID 1553a by the Sandoz Librarian.
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