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Uyeno ET. 
“Hallucinogenic compounds and swimming response”. 
J. Pharmacol.exp.Ther.. 1968;159:216-21.
The effects of several compounds and their nonhallucinogenic analogs were evaluated in an underwater swim alley. Rats were submerged and forced to swim underwater through plastic tubes 3.47 m long in order to escape at the other end of the tubes. All of the compounds tested significantly increased the starting latency but only d-amphetamine significantly increased swimming time. The peak effect time for d-lysergic acid diethylamide (LSD-25) and three amphetamine derivatives on latency was 20 min after the i.p. injection; that for 2-brom-lysergic acid diethylamide (BOL-148) was 40 min. Dose-response curves indicated that the increase in amphetamine (TMA-2) hydrochloride, 3,4,5-trimethoxyamphetamine (TMA) dydrochloride were 1.0, 11.0, 15.0, 31.0 36.5 and 77.0 mol/kg, respectively. An analysis of relative effectiveness indicated that LSD-25, TMA-2 and TMA (in descending order) were significantly more effective than their respective nonhallucinogenic analogs.
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