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Snyder SH, Richelson E. 
“Psychedelic drugs: Steric factors that predict psychotropic activity”. 
Proc.Nat.Acad Sci.. 1968;60:206-213.
Psychedelic drugs are a class of compounds that produce a characteristic set of profound and unique changes in human perception, thought, and feeling. There are at least three structurally dissimilar classes of psychedelic drugs: thy lysergic acid group, derivatives of tryptamine, and the compunds related to phenylethylamine or phenylisopropylamine. Within each of these structural classes, some compounds are potent psychedelic agents while others are ineffective. Several workers have attempted to find chemical or biological properties that are unique to active psychedelic agents of differing chemical structure. Effective psychedelic drugs that have been examined elevate brain concentrations of serotonin, and central sympathetic stimulation parallels psychedelic potency. It is probable that these compunds act on the same central receptor, since cross tolerance occurs between psychedlic drugs of such diverse structures as d-lysergic acid diethylamide (LSD), psilocybin, and mescaline.
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