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Cohen M, Wakely H. 
“A comparative behavioral study of ditran and LSD in mice, rats and dogs”. Pharacodyn. 1968;173, No 2:316-326.
Ditran and lysergic acid diethylamide (LSD) are know to produce different types of psychotomimetic effects in man. Ditran induces an apprehensive and anxious mood, predominantly auditory hallucinations, and little depersonalization, while LSD causes euphoria, predominantly visual hallucinations, and marked depersonalization (1-3). These differences may be due to the fact that ditran has many anticholinergic properties (2) and LSD resembles a sympathomimetic agent in many of its effects (4). While comparative studies of LSD and ditran have been performed in man, relatively little information is available from studies in animals. Thuiller et al (5) reported that both LSD and ditran potentiated barbiturate narcosis. However, LSD, but not ditran, was found to antagonize reserpine-and tetrabenazine-induced depression in rabbits and to produce a rapid dose-dependent hyperthermia in this species.
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