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Axt KJ, Mamounas LA, Molliver ME. 
“Structural Features of Amphetamine Neurotoxicity in the Brain. Amphetamine and its analogs: psychopharmacology, toxicology, and abuse”. 
Academic Press San Diego, CA. 1994;p315-367.
Amphetamine derivatives, like other psychotropic drugs, have the potential to affect neuronal function adversely, especially when administered chronically or in large doses. Such undesired drug effects may be manifested by alterations in behaviour, cognition, and mental function, and may result from abnoralities in biochemical, morphological, or physiological parameters. The potential for compensation or recover from such changes in brain function is contingent on the natuer of the morphological or functional changes that occur, as well as on whether a drug produced sutrctural damage to neurons. Other chapters in this volume depict many of the adverse biochemical and behavioural effects assocated with the use of amphetamine derivates; this chapter discusses several structural abnormalities in the brain that have been observed following administration of selected amphetamine derivatives.
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