Erowid References Database
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Anden NE, Corrodi H, Fuxe K, Hoekfelt T.
“Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide”.
Brit. J. Pharmacol.. 1968;34:1-17.
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Abstract
1. Lysergic acid diethylamide (LSD) and the 5-hydroxytryptamine (5-HT)
precursor, 5-hydroxytryptophan produced similar functional effects in rat
spinal cord and brain to the 5-hydroxytryptamine precursor 5-hydroxytryptophan,
which indicates that LSD stimulates central 5-HT receptors.
2. By means of combined histochemical and biochemical techniques it was
found that LSD reduced the turnover rate of brain and spinal cord 5-HT,
studied after inhibition of the tryptophan hydroxylase by a-propyldopacetamide.
The turnover of brain noradrenaline but not dopamine was somewhat
accelerated.
3. The functional and chemical effects by LSD were related to dose and to
time. They were not observed after the LSD analogues 2-bromo-LSD and
methysergide.
4. The retardation of the 5-HT turnover by LSD may be due to negative
feed-back mechanisms evoked by direct stimulation of the central 5-HT
receptors.
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