Erowid.org: Erowid Reference 501 : Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro : Cerruti C, Sheng P, Ladenheim B, Epstein CJ, Cadet JL

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Cerruti C, Sheng P, Ladenheim B, Epstein CJ, Cadet JL. “Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro”. Clin Exp Pharmacol Physiol. 1995;22(5):381-2. <a name="ref">Cerruti C, Sheng P, Ladenheim B, Epstein CJ, Cadet JL.</a> <a href="/references/501">"Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro"</a> <i>Clin Exp Pharmacol Physiol</i>. 1995;22(5):381-2.
Show Articles by Cerruti C Sheng P Ladenheim B Epstein CJ Cadet JL Article IDs Erowid RefID: 501 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract 1. Inhibitors of nitric oxide (NO) formation or ADP-ribosylation attenuate methamphetamine (METH)- and methylenedioxymetamphetamine (MDMA)-induced neurotoxicity on dopaminergic and serotonergic cells in primary cultures. 2. They also prevent METH-induced reactive gliosis in dopaminergic cultures. 3. Overexpression of superoxide dismutase (SOD) in cells obtained from SOD-transgenic mice also attenuates drug-induced toxicity. 4. These data indicate a role for oxygen-based and NO free radicals in the mechanisms of cell death associated with drugs of abuse in vitro.
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