Erowid.org: Erowid Reference 550 : 3,4-Methylenedioxymethamphetamine induces Fos-like proteins in rat basal ganglia: reversal with MK 801 : Dragunow M, Logan B, Laverty R

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Dragunow M, Logan B, Laverty R. “3,4-Methylenedioxymethamphetamine induces Fos-like proteins in rat basal ganglia: reversal with MK 801”. Eur J Pharmacol. 1991;206(3):255-8. <a name="ref">Dragunow M, Logan B, Laverty R.</a> <a href="/references/550">"3,4-Methylenedioxymethamphetamine induces Fos-like proteins in rat basal ganglia: reversal with MK 801"</a> <i>Eur J Pharmacol</i>. 1991;206(3):255-8.
Text Abstract (this page) Full Text - English (private) Show Articles by Dragunow M Logan B Laverty R Article IDs Erowid RefID: 550 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Injections of 3,4-methylenedioxymethamphetamine (MDMA, 25 mg/kg, i.p.) to rats lead to an accumulation of c-fos protein (Fos) and Fos-related antigens in caudate-putamen, nucleus accumbens and olfactory tubercle. This induction occurred at least 2 h (but not at 10 min) after injection and Fos levels had returned to baseline after 24 h, although Fos-related antigens remained elevated 24 h after injection. The NMDA antagonist MK 801 inhibited Fos and Fos-related antigen induction after MDMA injections, whereas fluoxetine, a serotonin uptake inhibitor, had no effect. Thus, MDMA induces Fos and Fos-related antigens in striatal neurons in an NMDA-reversible fashion.
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