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Parrott AC, Buchanan T, Scholey AB, Heffernan T, Ling J, Rodgers J. 
“Ecstasy/MDMA attributed problems reported by novice, moderate and heavy recreational users”. 
Hum Psychopharmacol. 2002 Oct 29;17(6):309-12.

RATIONALE: The recreational use of MDMA/Ecstasy (3,4-methylenedioxymethamphetamine) is associated with many psychobiological problems, but there is a paucity of data on how these relate to the level of past use.
OBJECTIVE: to assess the incidence of Ecstasy-attributed problems as reported by novice, moderate and heavy users.

METHODS: 763 unpaid volunteers took part in a WWW study of recreational drug use. This report is based on the 282 Ecstasy users from that sample, who comprised 109 novice users (1-9 occasions), 136 moderate users (10-99 occasions), and 36 heavy users (+100 occasions). Yes/no responses were automatically recorded to a series of questions covering psychobiological problems experienced when drug-free, which were attributed by the respondents to their Ecstasy use.

RESULTS: Depression, memory problems, anxiety, mood fluctuation, poor concentration, infections, tremors/twitches and weight loss, were all significantly associated with the extent of Ecstasy use. Thus memory problems attributed to Ecstasy were reported by 19% of novice users, 52% of heavy users and 73% of heavy users (chi-square 42.74, df=2, p< 0.001); many of the other variables showed similar trends. CONCLUSIONS: The incidence of problems attributed to Ecstasy use, is directly related to the number of occasions it has been used.
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