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Rosenberg H, Orkin FK, Springstead J. 
“Abuse of nitrous oxide”. 
Anesth Analg. 1979 Jun 29;58(2):104-6.
The results of an anonymous questionnaire showed that up to 20% of medical and dental students have utilized nitrous oxide in a social setting to produce a "high." Nitrous oxide was obtained from a variety of sources, most often from cylinders used in the production of whipped cream. Although none of the 524 respondents described personal injury with the use of nitrous oxide, a few individuals reported cyanosis, nausea, and syncope.
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