Erowid References Database
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Khorana N, Pullagurla MR, Dukat M, Young R, Glennon RA.
“Stimulus effects of three sulfur-containing psychoactive agents”.
Pharmacology, Biochemistry and Behavior. 2004;78:821-826.
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Abstract
Two agents gaining popularity on the illicit drug market are the phenylalkylamines 4-MTA and 2C-T-7 [or 1-(4-methylthiophenyl)-2-
aminopropane and 2-(2,5-dimethoxy-4-n-propylthiophenyl)-1-aminoethane, respectively]. At this time, there exists a paucity of information
on the behavioral actions of these sulfur-containing agents. The present investigation examined these agents, and the N-monomethyl analog
of 4-MTA (i.e., 4-MTMA), in tests of stimulus generalization (substitution) using a two-lever drug discrimination task with groups of rats
trained to discriminate either the hallucinogen DOM [1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane], the stimulant cocaine, or the
empathogen MDMA from vehicle. 4-MTA and its N-monomethyl analog 4-MTMA (ED50 = 0.8 mg/kg in both cases) substituted only for the
MDMA stimulus, whereas 2C-T-7 (ED50 = 0.8 mg/kg) substituted only for the DOM stimulus. Thus, at the doses examined, 4-MTA and 4-
MTMA appear to be MDMA-like agents, and 2C-T-7 seems best classified as a DOM-like hallucinogen. These results provide additional data
that extend the structure–activity relationships of phenylalkylamines and that are consistent with what little is currently known about the
action of 4-MTA and 2C-T-7 in humans.
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