Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Seiden LS, Fischman MW, Schuster CR. 
“Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys”. 
Drug Alcohol Depend. 1976 Feb;1(3):215-9.
d-Amphetamine, methamphetamine and other phenethylamines cause decreases in food intake, stereotypic behavior, disruption of behavior that is under stimulus control, as well as general sympathomimetic effects such as hyperthermia, increased blood pressure and piloerection. The doses required to produce different effects vary. In addition, most psychomotor stimulants are subject to abuse in man and will be self-administered by ani- mals [1]. Repeated administration of the amphetamines leads to the devel- opment of tolerance to many of its effects on behavior although the degree of tolerance depends to a large extent on the frequency of administration, the dose, the route of administration and the behavior in question. Several investigators have presented evidence that amphetamines exert their effects upon behavior by increasing the concentration of catecholamines at the synaptic cleft by blocking re-uptake and/or promoting release.
Comments and Responses to this Article
Status: display
Apr 17, 2011 1:59
First Paper Documenting Methamhetamine Neurotox #

This is considered to be the first paper to show that methamphetamine causes neurotoxicity, by showing that it caused norepinephrine (NE) and dopamine (DA) reductions in rhesus monkeys.
Submit Comment
[ Cite HTML ]