Erowid.org: Erowid Reference 644 : Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain : Hashimoto K, Maeda H, Goromaru T

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Hashimoto K, Maeda H, Goromaru T. “Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain”. Brain Res. 1992;590(1-2):341-4. <a name="ref">Hashimoto K, Maeda H, Goromaru T.</a> <a href="/references/644">"Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain"</a> <i>Brain Res</i>. 1992;590(1-2):341-4.
Text Abstract (this page) Full Text - English (private) Show Articles by Hashimoto K Maeda H Goromaru T Article IDs Erowid RefID: 644 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [3H]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these benzylpiperazines may inhibit the MDMA-induced neurotoxicity by a novel neuropharmacological effect other than 5-HT uptake inhibition.
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