Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE. 
“Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)”. 
J Med Chem. 1998 Mar 12;41(6):1001-5.
The three isomeric ring-methylated derivatives of the well-known hallucinogen and entactogen MDA (1a) were synthesized and evaluated for pharmacological activity as monoamine-releasing agents and as serotonin agonists. The 2-methyl derivative 2a and the 5-methyl derivative 2b were found to be more potent and more selective than the parent compound in inhibiting [3H]-serotonin accumulation in rat brain synaptosomal preparations. Their activity in vivo was confirmed in rats trained to discriminate serotonin-releasing agents and hallucinogens from saline. The results indicate that compounds 2a,b are among the most potent 5-HT-releasing compounds known and show promise as lead compounds in the search for antidepressant drugs that release serotonin rather than inhibit its uptake.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]