Erowid References Database
Braun U, Shulgin AT, Braun G, Sargent T III.
“Synthesis and Body Distribution of Several Iodine-131 Labeled Centrally Acting Drugs”.
Journal of Medicinal Chemistry. 1977 Dec;20(12):1543-6.
1-(4-1odo-2,5-dimethoxypheny1)-2-aminopropane (3b), 4-iodo-2,5-dimethoxyphenylethylamine (3a), and 1-(4-
iodo-2,5-dimethoxyphenyl)-2-aminobutane (313) have been synthesized with I3'I. Labeled iodine monochloride reacts with the appropriately substituted phthalimide at the aromatic 4 position, and the phthalic acid group is removed with hydrazine. Body distribution was measured in rats; the most prominent difference between the three compounds
was a much greater concentration in the lung with 3b than with 3a or 3c. y-Ray scintigraphs of 3a-c in rats and of 3b in a dog indicate an uptake by the brain similar to that of the bromine analogue of 3b (DOB) in humans. [82Br]-DOB has been suggested as a potential brain scanning agent for nuclear medicine; 3b would have the advantage over DOB of providing the superior y-ray imaging properties of I3'I or 1231.
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