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Kulmala HK, Boja JW, Schechter MD. 
“Behavioral suppression following 3,4-methylenenedioxymethamphetamine”. 
Life Sci. 1987;41(11):1425-9.
Rotation in rats was employed as an assay of the central dopaminergic activity of 3,4-methylenedioxymethamphetamine (MDMA). This agent was observed to possess predominantly amphetamine-like actions at low doses. However, at higher doses it also appears to stimulate the dopamine receptor directly. Following a third dose of MDMA, a significant decrease in rotation was evident to this drug and to amphetamine, suggesting a neurotoxic or long-term suppressive action of MDMA.
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