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Kovera CA, Kovera MB, Singleton EG, Ervin FR, Williams IC, Mash DC. 
“Decreased Drug Craving During Inpatient Detoxification with Ibogaine”. 
Paper presented at the meeting of the College on Problems of Drug Dependence. 1998 June.
Previous observations of ibogaine's effects have indicated that it may be useful for reducing drug craving for a significant period. The present study involved administration of a single psychoactive dose of ibogaine in a clinical setting to treatment-seeking patients having a chemical dependency on opiates or cocaine. Patients underwent Structured Clinical Interviews for assignment of Axis I and Axis II diagnoses, with admission and outcome measures of life improvement or impairment given by summary scores from the Addiction Severity Index. Patients reported three times on aspects of craving by completing "at-the-moment" craving questionnaires for cocaine (CCQ-NOW and MCCS), and heroin (HCQ-29-NOW), as well as their health symptoms and mood via the SCL90-R, BDI, and POMS. In terms of the four factors found by Tiffany et. al. (1993) to be common to the CCQ-NOW and the HCQ-NOW, preliminary analyses show decreased heroin and cocaine craving following ibogaine, especially at nine days after treatment. Decreased cocaine craving was supported by reduced scores in the visual analog scales of the MCCS, and reduced frequency and duration of "craving" episodes. On global scores from mood and health questionnaires, patients reported few to no withdrawal signs or negative health consequences following treatment, suggesting that single-dose ibbigaine may assist chemically-dependent individuals in the early stages of abstinence. Sponsored in part by the Addiction Research Foundation.
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