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Alexander BK, Beyerstein BL, Hadaway PF, Coambs RB. 
“Effect of early and later colony housing on oral ingestion of morphine in rats”. 
Pharmacol Biochem Behav. 1981 Oct 22;15(4):571-6.
Male and female rats were raised from weaning either in isolation or in a large colony. At 65 days of age, half the rats in each environment were moved to the other. At 80 days, the animals were given continuous access to water and to a sequence of 7 solutions: 3 sweet or bitter-sweet control solutions and 4 different concentrations of morphine hydrochloride (MHCl) in 10% sucrose solution. Rats housed in the colony at the time of testing drank less MHCl solution than isolated rats, but no less of the control solutions. Colony-dwelling rats previously housed in isolation tended to drink more MHCl solution than those housed in the colony since weaning, but this effect reached statistical significance only at the lowest concentration of MHCl. These data were related to the hypothesis that colony rats avoid morphine because it interferes with complex, species-specific behavior.
Notes # : rat park follow-on
Comments and Responses to this Article
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Apr 17, 2011 1:59
Marred by Data Loss #

Unfortunately this paper is marred by a glitch in their recordings: 'A persistent electronic malfunction caused the loss of several day's data from the colony rats.' It did not invalidate the results, but it weakens them.
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