Erowid References Database
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Friedhoff AJ, Schweitzer JW, Miller J.
“Biosynthesis of mescaline and N-acetylmescaline by mammalian liver”.
Nature. 1972 Jun 12;237(5356):454-5.
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Abstract
We have shown that mescaline, a well established hallucinogen found in the peyote cactus, can also be formed by mammalian liver from an appropriate precursor. An enzyme can be extracted from various mammalian tissues (by centrifugation at 100,000g for 1 h), including human brain and liver that transfers a rnethyl group from S-adenosyl[Me-14C]methionine (14C-SAM) to 4-O-methylated catecholamine metabolites to form corresponding 3,4-di-O-methylated compounds1,2. One of the substrates for this enzyme is iso-N-acetylmethoxytyr-amine (i-NAMT), which is converted to N-acetyl-3,4-di-methoxy- I came across this 1972 abstract describing mescaline biosynthesis in mammalian liver.
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