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Glick SD, Jarvik ME, Nakamura RK. 
“Inhibition by drugs of smoking behaviour in monkeys”. 
Nature. 1970 Aug 28;227(5261):969-71.
THERE have been several analyses of the role of nicotine in smoking. Johnston found that heavy smokers reported a pleasurable sensation when given nicotine, whereas non-smokers reported an unpleasant effect. Lucchesi et al. showed that intravenous administration of nicotine diminished the number of cigarettes smoked by heavy smokers. Jarvik et al. recently obtained a similar result with nicotine taken orally. If, as these studies suggest, nicotine is an incentive in smoking, then drugs which block the action(s) of nicotine should influence smoking.
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