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Andén NE, Corrodi H, Fuxe K, Meek JL. 
“Hallucinogenic Phenylethylamines: Interactions with Serotonin Turnover and Receptors”. 
Eur J Pharmacol. 1974 Feb 10;25(2):176-84.
The effects of derivatives of phenylethylamine and a-methyl-phenylethylamine (2,5-dimethoxy4-methylamphetamine, p-metboxyamphetamine, mescaline, p-methoxyphenylethylamine, 3,4-dimethoxyphenylethylamine) have been studied on 5-hydroxytryptamine (5-HT) turnover and receptors in the rat brain and spinal cord. Both p-methoxyamphetamine (pMA) and 2,5-dimethoxy-4-methylamphetamine (STP, DOM) in doses of 5 mg/kg but not even high doses of mescaline, 50 mg/kg, reduced 5-HT turnover in the CNS. This reduction did not appear to be related to irreversible MAO inhibition but was probably due to direct stimulation of 5-HT receptors. Evidence for receptor stimulation was obtained on the extensor hindlimb reflex of the acutely spinalized rat; p-methoxyphenylethylamine (pMPEA) but not 3,4-dimethoxyphenylethylamine (DIMPEA) directly stimulated 5-HT receptors. The 5-HT receptor stimulation induced by DOM and pMA, via a feedback mechanism probably inhibits the presynaptic 5-HT neurons with subsequent reduction of 5-HT release and 5-HT turnover. We propose the hypothesis that the 5-HT receptor stimulation induced by the psychotomimetic phenylethylamines is mainly responsible for their pharmacological and hallucinogenic properties.
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