Erowid References Database
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Beaton JM, Benington F, Bradley RJ, Kuhlemeier KV, Morin RD.
“Stereospecific actions of 2,5-dimethoxy-4-methylamphetamine DOM on colonic temperature in the rat at various ambient temperatures”.
Br J Pharmacol. 1976 Aug 21;57(4):547-50.
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Abstract
The R- and S+-isomers of 2,5-dimethoxy-4-methylamphetamine DOM produce a dose-dependent hypothermia in rats kept in the cold 6 degrees C. 2 This hypothermia was linearly dependent upon ambient temperature and the R--isomer was considerably more potent than the S+-isomer. 3 A statistically significant tachyphylaxis was observed when R--DOM was administered on two successive days. The response seven days after the second injection was similar to that on the first day of injection. 4 The hypothermia induced by R- and S+-DOM was antagonized by methysergide but not by p-chlorophenylalanine PCPA or pimozide. Methysergide, PCPA or pimozide alone did not elicit hypothermia at the doses used. The results indicate that R- and S+-DOM act at post-synaptic 5-hydroxytryptamine receptors.
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