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Meyer MR, Maurer HH. 
“Metabolism of designer drugs of abuse: an updated review”. 
Curr Drug Metab. 2010 Jun 16;11(5):468-82.
This paper reviews the metabolism of new designer drugs of abuse that have emerged on the black market during the last years and is an update of a review published in 2005. The presented review contains data concerning the so-called 2C compounds phenethylamine type such as 4-bromo-2,5-dimethoxy-beta-phenethylamine 2C-B, 4-iodo-2,5-dimethoxy-beta-phenethylamine 2C-I, 2,5-dimethoxy-4-methyl-beta-phenethylamine 2C-D, 4-ethyl-2,5-dimethoxy-beta-phenethylamine 2C-E, 4-ethylthio-2,5-dimethoxy-beta-phenethylamine 2C-T-2, and 2,5-dimethoxy-4-propylthio-beta-phenethylamine 2C-T-7, beta-keto designer drugs such as 2-methylamino-1-3,4-methylenedioxyphenylbutan-1-one butylone, bk-MBDB, 2-ethylamino-1-3,4-methylenedioxyphenylpropan-1-one ethylone, bk-MDEA, 2-methylamino-1-3,4-methylene notdioxy notphenylpropan-1-one methylone, bk-MDMA, and 2-methylamino-1-p-tolylpropane-1-one mephedrone, 4-methyl-methcathinone, pyrrolidino notphenones such as 4-methyl-pyrrolidinobutyrophenone MPBP and alpha-pyrrolidinovalerophenone PVP, phencyclidine-derived drugs such as N 1 phenylcyclohexyl propanamine PCPr, N-1-phenylcyclohexyl-2-ethoxyethanamine PCEEA, N-1-phenylcyclohexyl-3-methoxypropanamine PCMPA, and N-1-phenylcyclohexyl-2-methoxyethanamine PCMEA, tryptamines such as 5-methoxy-N,N-diisopropyl nottryptamine 5-MeO-DIPT, and finally alpha-methylfentanyl alpha-MF and 3-methylfentanyl 3-MF. Papers have been considered and reviewed on the identification of in vivo or in vitro human or animal metabolites and the cytochrome P450 or monoamineoxidase isoenzyme-dependent metabolism.
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