Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Aldous FA, Barrass BC, Brewster K, Buxton DA, Green DM, Pinder RM, Rich P, Skeels M, Tutt KJ. 
“Structure-activity relationships in psychotomimetic phenylalkylamines”. 
J Med Chem. 1974 Oct 14;17(10):1100-11.
A study has been made of the relationship between the structure of phenylalkylamines and potential correlates of their psychotomimetic activity. Optimum activity is associated with a an isopropylamine side chain, with a R-- configuration at the carbon atom a to the amino group, and b 2,5-dimethoxy substitution, together with an alkyl or halo group at position 4 that is probably limited in bulk to n-propyl or bromo. The activity of compounds in producing hyperthermia in rabbits provides good quantitative correlation with reported psychotomimetic activities in man.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]