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Lin JC, Jan RK, Lee H, Jensen MA, Kydd RR, Russell BR. 
“Determining the subjective and physiological effects of BZP combined with TFMPP in human males”. 
Psychopharmacology Berl. 2010 Nov 9.

RATIONALE: 'Party Pills' containing benzylpiperazine BZP and trifluoromethylphenylpiperazine TFMPP have been used in a recreational context since the 1990s and, prior to April 2008, were legally available in New Zealand. Taken together, they have been reported to produce a 'high' similar to that produced by 3,4-methylenedioxymethamphetamine MDMA.
OBJECTIVE: There has been little research on the subjective effects of piperazines in humans. The purpose of this study is to further investigate the subjective and physiological responses following an oral dose of BZP combined with TFMPP in males.

METHODS: In a randomised, double-blind, placebo-controlled study the subjective and physiological effects of BZP/TFMPP were investigated in 36 healthy, non-smoking males mean age 22 ± 4 years. Participants were tested before and approximately 120 min after administration of a single dose of placebo n = 16 or 100/30 mg BZP/TFMPP n = 20. Participants were required to comment on the subjective effects using three rating scales-the Addiction Research Centre Inventory ARCI, the Visual Analogue Scale VAS and the Profile of Mood States POMS. Participants' blood pressure, heart rate and body temperature were also measured.

RESULTS: Statistical analysis using repeated-measures analysis of variance ANOVA and planned comparisons revealed that BZP/TFMPP significantly increases blood pressure and heart rate p < 0.05. Likewise, the subjective rating scales revealed that BZP/TFMPP has significant dexamphetamine-like effects, increases dysphoria and feelings of self-confidence p < 0.05. CONCLUSION: These physiological and subjective data reflect clear similarities between the effects of BZP/TFMPP and commonly known stimulants such as dexamphetamine and MDMA.
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