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Corrigall WA, Coen KM, Saouda FM, Robertson JM, Lodge BA. 
“Discriminative Stimulus Properties of Substituted Amphetamine Derivatives”. 
Pharmacol Biochem Behav. 1992 Jan. 28;43:1117-9.
Animals were trained to discriminate amphetamine 1 mg/kg from saline in a fixed-ratio FR 10, food-reinforced paradigm. Amphetamine-appropriate responding was engendered by the training dose, and by 3 mg/kg, while at lower doses there was a progressive decrease in the extent of responding on the drug-appropriate lever. The following three novel amphetamine derivatives were tested for their ability to produce amphetamine-appropriate responding: 2,5-dimethoxy-4-ethoxyamphetamine DMEA 2,5-dimethoxy-4-methylthio-amphetamine DMMTA, and 2,4,5-trimethoxy-amphetamine TMA. DMEA produced only minimal < 20/o amphetamine-appropriate responding over a dose range of 0.1-10 mg/kg. Substantial decreases in response rate limited testing of the other amphetamines to a dose maximum of 3 mg/kg, but over the range of 0.1-3.0 mg/kg there was little evidence for generalization. At 3 mg/kg of either DMMTA or TMA, only 2 of 10 animals completed at least one uninterrupted FR 10 on either lever, and with either compound only I of these 2 animals responded more than 50 on the drug-appropriate lever. Of the three compounds tested, DMMTA had the greatest response rate-decreasing effect.
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