Erowid References Database
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Murphree HB Jr, Jenney EH, Pfeiffer CC.
“Comparison of the effects of congeners of lysergic acid diethylamide and tryptophane in normal volunteers”.
The Pharmacologist. 1960;2(2):64.
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Summary
Comparison was made in normal human volunteers of the effects of l-lyserglc acid diethylamide, dl-alpha-methyl tryptamine, 5-hydroxytryptamine, dl-DOPA, d-DOPA and l-DOPA with d-lysergic acid diethylamide. The subjects were highly trained to recognize the effects of d-LSD and other hallucinogens. All compounds were given orally. Blood pressure, pulse rates, pupil diameter, body temperature, hand steadiness were measured at hourly intervals, and the subjects kept running diaries of subjective effects. l-LSD was previously reported by this department to have no effect in doses up to 2 mg. In this
study, dosage was increased progressively to 10 mg with no effect. It was concluded that: 1 the preparation was highly pure, 2 no racemlzatlon occurred in the body, and 3 the
levo-isomer is less active than the dextro- by a factor greater than 400:1. dl-
alpha-methyl tryptamine in a dose of 20 mg produced a subjective action similar to 50 µg of d-LSD. The effects appeared later, however, with a lag up to three hours. 5-hydroxytryptamlne in a dose of 100 mg produced a fall in systolic and a rise in diastolic blood pressures together with a feeling of sedation, abdominal cramping, and muscle aching similar to those of d-LSD. Effects were delayed 6 to 8 hours after dosage. Oral D0PA produced no tangible CNS effects.
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| Notes # : Title of Abstract mentions 5-hydroxytryptophan (aka oxitriptan), while abstract text only mentions 5-hydroxytryptamine (aka serotonin); it is not clear which chemical was used. |
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