Erowid.org: Erowid Reference 8257 : An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification : Dubowchik GM, Michne JA, Zuev D

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Dubowchik GM, Michne JA, Zuev D. “An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification”. Bioorg Med Chem Lett. 2004 Jun 19;14(12):3147-9. <a name="ref">Dubowchik GM, Michne JA, Zuev D.</a> <a href="/references/8257">"An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification"</a> <i>Bioorg Med Chem Lett</i>. 2004 Jun 19;14(12):3147-9.
Text Abstract (this page) Full Text - English (private) Show Articles by Dubowchik GM Michne JA Zuev D Article IDs Erowid RefID: 8257 PubMedID: 15149663 Collections Hofmann Collection MDMA Collection All References	Abstract Collections of small secondary amines for compound library generation can be efficiently prepared by amide reduction using BH3-THF or Red-Al followed by brief methanolysis, trapping with di-tert-butyl dicarbonate, and deprotection with 4M HCl in dioxane. The sequence requires no chromatography or distillation and provides multi-gram quantities of pure HCl salts in a short time.
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